OSPHOSIL®

An innovative active with organic silicon and phosphorus

BONE & JOINT HEALTH

 Patented molecule

 Highly bioavailable

  High potential in
arthrosis treatment

 

ORIGIN

Silicon, the 2nd most abundant element on Earth

 

 

 

 Different forms of silicon exist: mineral forms and active forms. The best bioavailable form of silicon for human use is water soluble organic silicon, also known as silanol. Osteosil is a highly efficient and innovative molecule of silanol and phosphorus made to support healthy bones and joints by increasing the silicon bioavailability in articular tissues and collagen type 1 production.

 

BENEFITS

 

 

Main benefits Activities
JOINTS HEALTH Reduction of cartilage lesions by inhibiting enzymatic activity of stromelysin and collagenase1
Anti-inflammatory activity

Enhancement of cartilage hyaluronic acid content
BONES HEALTH Positive association between a silicon-rich diet and a high bones mineral density
Stabilization of macromolecules such as hyaluronic acid and glycosaminoglycans
Bone formation by stimulating osteoblasts (ECM creating cells) and inhibiting osteoclasts (ECM degrading cells)
Reduction of osteophyte formation

MODE OF ACTION

Multiple actions to support healthy bones and joints2


SCIENCE-BASED EVIDENCE

Scientifically proven anti-arthrosis properties3,4

 

 Ex vivo study on human chondrocytes evaluating the effects of Osteosil® on the activity of the
metalloprotease stromelysin, a key enzyme in cartilage degradation implicated in osteoarthritis and responsible for articular lesions.

 

 

 

 

IL-1 β (interleukin 1 β) is a pro-inflammatory cytokine triggering the activation of stromelysin.

 

 

 

When OSTEOSIL® is added in the medium, the activity of stromelysin significantly decreases in a dose-dependant manner.

 

Bibliographical references

1. Dietary Silicon Intake Is Positively Associated With Bone Mineral Density in Men and Premenopausal Women of the Framingham Offspring Cohort. Ravin Jugdaohsingh, 2003
2. Ex vivo study on human chondrocytes, 1996
3. M.Q. Arumugam et al. Orthosilicic Acid Increases Collagen type 1 mRNA expression in human bone-derived osteaoblasts in vitro. Key Engineering Materials, 2014
4. Pr. J.Y. Reginster, Dr. Y. Henrotin, Bone and Joint Investigation Center

MORE DETAILS ON OSPHOSIL®

Technical data sheet
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