A patented dry extract high in
A neuroprotective peptidomimetic
for fat control
High potential on neuroslimming
A patented peptidomimetic with neuroprotective properties
Pyroglutamylamidoethyl indole (pGT) is a dipeptide obtained with a cascade of several chemical reactions from two natural products. The initial raw material is tryptophan produced by fermentation. This tryptophan is then converted in tryptamine thanks to a decarboxylation. Tryptamine undergoes a coupling with beetroot glutamic acid which finally produces pGT.
A new approach to improve lipolytic effect of nerve ending
With ageing or chronic emotional stress, communication between nerves ending and adipocytes can be damaged and leads to a decrease in fat mobilizing capacity.
Modulip® improves neuronal response to Nerve Growth Factor (NGF) which allows to increase pro-lipolytic mediator production. It finally leads to a better lipolysis performance mainly focused on abdominal fat. Modulip® has also a specific action on white adipose tissue which is composed of adipocytes with a fat synthesis, storage and liberation function.
Effect of pGT on cortisol-mediated PC12 regression and lipolysis (in vitro study)1
When cortisol isadded to PC12 (a neuronal line which acquires the secretory pattern of sympathetic neurons upon stimulation with NGF), itantagonizes NGF effect and inhibitsneutrix network development. Addition of pGTlimitsdeleteriouseffects of cortisol on neuronal network.
Lipolysis enhances with increasing concentrations of pGT.
Improved metabolic activity of the sympathetic neurons to adipose tissue increases the « sympathetic lypolitic drive ».
Enhancement of the neurons ability to support the lipolysis process by the adipocytes3
Increase in collagen and elastin production4
Protection of neurons from the NGF drop-induced neurodegenerescence5
1. Preservation of Sympathetic Neuron-Adipocyte Crosstalk May Limit Chronic Emotional Stress-Mediated Fat Accu-mulation. Pascale Prouheze, Barbara Morand, Jean-François Nicolaÿ and Mathilde Fréchet. 2013
2. Exsymol, 2010
3. Neurotrophic stimulation of aged fibroblasts improves TGF-β expression and ECM remodeling in a dermal equivalent model. Golebiewski Christelle, Prouheze Pascale, Nicolaÿ Jean-François and Frechet Mathilde. 2012
4. Exsymol, 2007 – DO_1086