Collasil® OSA

The amazing technologic combination between bioavailable Silicic acid and low density marine collagen – Bruno Zylbergeld, PhD – Magazine Actif’s – 

Silicon

The planet earth is endowed with both animate and inanimate entities. The former comprises of all life forms on earth including microorganisms, plants and animals varying in size and form and diverse in habitats. Yet all of them are made up of carbonaceous materials, perish after a life span, fall on earth as debris and degraded rapidly or slowly ultimately turning into carbon and ash containing the minerals. The inanimate solid mass, the soil, including rocks and minerals buried underneath, are non-degradable, water insoluble and therefore everlasting as a substratum is made up of silicon compounds that serve for the foot hold for animals and anchorage for plants simultaneously serving as a repository of nutrients to plants It is important to note that life forms are made up of carbon compounds that are biodegradable and soil is made up of silicon compounds that are not biodegradable and this trait keeps life forms to come, live and leave the earth but soil remains forever sustaining all of them. Silicon is an element of earth and carbon is a non-mineral element of life (Vasanthi et al 2012).

In the biological system the Orthosilicic acid was already related with promotion of bone formation and to regulating connective tissue synthesis in rats (Schwartz, 1972) and chicks (Carlisle, 1997). It was implicated in mammalian hormonal control (Charnot, 1977) and it protected against heart disease in man (Loeper, 1977). A new era of our understanding of silicon in biology was heralded (Exley, 1998).

There is a narrow range of Si concentration in the serum of healthy adults. No difference between the sexes was demonstrated. With the exception of urine, the concentrations of Si in all other body fluids examined was similar to that of normal serum. These findings indicate that Si is freely diffusible throughout tissue fluid. The higher levels and wider range encountered in urine suggest that the kidney is the main excretory organ for Si absorbed from the alimentary canal (Dobbie, 1982).

UTHUS et SEABORN-1996 (American department of agriculture) precising that in man, the bioavailability of silicon provided by food is weak and diminished with age and the decline of the oestrogenic permeation.

The normal silicon supply in the organism starts in the fetus, via the placenta. All the fetal tissue of man contains silicon, the most rich being that of the brain, muscle and the spleen. After birth, this order modifies due to the different organs becoming functional (HUGUET ET AL, 1991).

The role of silicon in human body

Silicon, bone formation and regeneration

Silicon is bound to glycosaminoglycans and has an important role in the formation of cross-links between collagen and proteoglycans (Schwarz, 1973). Silicon is present in all body tissues, but the tissues with the highest concentrations of silicon are bone and other connective tissue including skin, hair, arteries, and nails The exact sequence of mineralization is unknown, but Carlisle concluded that silicon probably acts by making the bone matrix more calcifiable (Carlisle, 1981)

Osteoporosis and silicon intake

Diets containing more than 40 mg/day of silicon have been positively associated with increased femoral bone mineral density compared to dietary intake of less than 14 mg/day (Tucker Et al, 2004).

Vascular health and protection against atherosclerotic plaque 

Schwarz reported an inverse association between silicon concentrations in drinking water and the number of deaths from cardiovascular disease in Finland. He proposed that a lack of silicon in the diet and in drinking water may contribute to the etiology of the disease, whereas sufficiency or excess may inhibit disease development. A similar association was reported by Dawson et al.. Indeed, silicon administered intravenously or orally to cholesterol-fed rabbits greatly reduced, and almost negated, the formation of cholesterol plaques. Maehira et al. reported that soluble silica significantly reduced systolic blood pressure in spontaneously hypertensive rats, suggesting that silicon may reduce hypertension. Buffoli et al. reported in a mouse model of physiologic aging that silicon supple-mentation in drinking water can protect against age-related vascular aging. These findings suggest a potential role for dietary silicon in vascular health, although the mechanism of action is unclear (Jugdaohsingh, 2015).

Si and Aluminum (Al) serum reduction

It has been reported that Si is a decisive factor in limiting absorption of dietary Aluminium (Edwardson, 2003). Si administration reduced Al accumulation in several tissues, including brain areas of rats orally exposed to Al (Belles, 1997).Si has been associated with protective effects in the Alzheimer’s disease and human neuroblastoma (Garcimartin, 2014).

Silicon and elderly

CARLISLE -1984 indicated that modifications of the connective tissue are important with age. During the fetal development, the silicon level increases. We note then throughout life a relation between the silicon content and the aging of certain tissues. The decline of the silicon content is particularly significant in the aorta, other arterial vessels and in the skin in relation to other organs where the decline is weakly seen.
This relation is present in many species such as rabbits, rats, chickens and pigs.
LOEPER et AL-1966 have indicated that the silicon contained in the aorta diminished significantly with age, as in the arterial walls at the development of arteriosclerosis.
In conclusion, all these results converge to show that in man, there is a decline with age of both the supply and the silicon content of the organism.

Action of silicon against the effects of aging

From the many studies undertaken, we note that in man as in animal there is a reduction in the silicon content with age, particularly in tissue normally rich in this element: connective tissue.
All the studies concerning silicon deficiency on animals have shown an abnormal development of the skeleton and connective tissue, the reintroduction later of silicon allows for a correction of this anomaly.
The silicon acts on the extracellular matrix of the connective tissue, particularly on the collagen fibres.
SEABORN & NIELSEN -2002 have tested a diet poor in silicon on rats and have evaluated the incidence on the collagen synthesis. Following an injury, we note a reduction of the collagen synthesis and clinically, a lengthening of the scar duration.

Silicon and Collagen

Through new studies evidence is accumulating to suggest that, in mammals, silicon plays an important role in optimal connective tissue health (Jugdaohsingh, 2007). Its exact role/function remains unestablished, but there is evidence to suggest it’s involved in the synthesis and/or stabilization of extracellular matrix components, namely collagen, and in the proliferation of connective tissue cells (Jugdaohsingh, 2008).

It is very important to note that almost all collagen in the body needs silicon under the cellular matrix to induce the formation of collagen and promote the right anchoring into the adjacent tissue.

Collagen

Collagens are the most abundant proteins in mammals. The collagen family comprises 28 members that contain at least one triple-helical domain. Collagens are deposited in the extra cellular matrix where most of them form supramolecular assemblies. Four collagens are type II membrane proteins that also exist in a soluble form released from the cell surface by shedding. Collagens play structural roles and contribute to mechanical properties, organization, and shape of tissues. They interact with cells via several receptor families and regulate their proliferation, migration, and differentiation. Some collagens have a restricted tissue distri¬bution and hence specific biological functions (Blum, 2011).

Since collagen is present and distributed throughout the body and its formation depends on silicon, it would be right to say that silicon is essential to the maintaining of the most abundant protein in the body. It is noteworthy that the collagen is present in all body tissues less blood tissue.

Collasil® OSA

Food ingredient constituting a stabilized silicic acid on a hydrolyzed of marine collagen (gelatine) which is destined to supply bioavailable silicon in the form of a food complement.
Collasil® OSA has an original patented structure composed of two substances very well known: silicic acid and a hydrolyzed fish collagen. The innovation are based on the mode of association which puts a limitation on the polymerization of the silicic acid and therefore renders it more bioavailable, because silicic acid, silicon dioxide and some others form of silicon, when mixed in aqueous medium polymerizes immediately preventing its uptake and delivery to the body.

Many criteria are at the origin of the choice of the hydrolysate of marine collagen as a support for the silicic acid:

  • Allowing the silicic acid to be stabilized and avoid its polycondensation.
  • Food grade product.
  • Non GMO.
  • Not from bovine origin eliminating all risk of BSE.
  • Not from pork origin for religious reasons.
  • Product has a potentiated effect on the silicon of connective tissue.

Collasil® OSA formulation

Silicic acid (= in Silicon)

5% (1.5%)

Hydrolized fish collagen (4 KDa)

90%

Choride

3.50%

Water

s.q.100% 

Collasil® OSA bioavailability

Quantification of silicon in urine after oral administration.

 

 The results obtained, confirm the very weak bioavailability of the silica in the colloidal form or in a reduced form compare to Collasil® OSA. The same was seen for the powdered horsetail silicon source. If we estimate that the type of silicon contained in this plant is representative of the silicon content in other vegetables, the results obtained coincide with the bibliographical information (UTHUS et SEABORN-1996), which indicates in particular that the silicon content in plants and in the majority of food diets is only weakly absorbed.

Nutritional facts

Energy value 360 kcal/1530 kj
Proteins  90 g
Carbohydrates  0 g
Fats  0 g
Sodium  0.2 g
Potassium  < 0.01 g
Calcium  < 0.05 g
Silicon  1.5 g
Chloride  3.50%

Aminogram 

Amino acid

g/100 g

Alanine

9,9

Arginine

8,8

Aspartic acid

5,7

Cystine

0

Glutamic acid

9

Glycine

23,4

Histidine

1,3

Isoleucine

1

Leucine

2,8

lysine

3,3

Methionine

1,3

Phenylalanine

1,9

proline

12,7

Serine

3,6

Threonine

2,9

Tryptophan

0

Tyrosine

0,5

Valine

1,8

Hydroxyproline

9,2

Hydroxylysine

1,1


Justification of the recommended dose

In function of the information previously presented concerning the decline of the silicon supply with age, we suggest for persons 40 plus, a daily intake of between 60-600 mg/day of COLLASIL® OSA or approximately 1 – 10 mg/day of total silicon.
We recommend 600 mg / d at the beginning (during 2 weeks for instance) and after 300 mg / d (= 5 mg/d in silicon).
The dosage definition was based on the publication of UTHUS et SEABORN-1996. , member of the American Department of Agriculture have in effect determined that the necessary quantities of bioavailable silicon to cover the needs of an adult man need to be between 2 & 5 mg/day.

 

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Bibliographical references

N. Vasanthi, L. M. Saleena, S. A. Raj. Silicon in Day Today Life, World Applied Sciences Journal 17 (11): 1425-1440, 2012.
Schwarz K, Milne DB. Growth promoting effects of silicon in rats.Nature 1972;239:333–4.
Carlisle EM. Silicon. In: O’Dell BL, Sunde RA, eds. Handbook ofnutritionally essential mineral elements. New York: Marcel DekkerInc, 1997:603–18.
Charnot Y, Pérès G. Change in the absorption and tissue metabolism of silicon inrelation to age, sex and various endocrine glands. Lyon Med 1971;13:85.
Loeper J, Fragny M. The physiological role of the silicon and itsantiatheromatous action. In: Bendz G, Lindqvist I, editors. Biochemistry of siliconand related problems. New York: Plenum Press; 1978. p. 281–96.
Jugdaohsingh, R. “Silicon and bone health.” The journal of nutrition, health & aging 11.2 (2007): 99.
Edwardson, J. A., et al. “Effect of silicon on gastrointestinal absorption of aluminium.” The Lancet 342.8865 (1993): 211-212.
Garcimartín, J.Merino, M.P. González, M. I. Sánchez-Reus, F.J Sánchez-Muniz,S. Bastida and J. Benedí. Organic silicon protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide effects, Garcimartín et al. BMC Complementary and Alternative Medicine 2014, 14:384.
M. Q. Arumugam, D.C. Ireland, R.A. Brooks, N. Rushton, W. Bonfield. Orthosilicic Acid Increases Collagen Type I mRNA Expression in Human Bone-Derived Osteoblasts In Vitro, Key Engineering Materials Vols 254-256 (2004) pp 869-© (2004) Trans Tech Publications, Switzerlanddoi:10.4028/www.scientific.net/KEM.254-256.869
Seaborn, C. D., and F. H. Nielsen. “Silicon deprivation decreases collagen formation in wounds and bone, and ornithine transaminase enzyme activity in liver.” Biological trace element research 89.3 (2002): 251-261.
K L Tucker et al., ‘Dietary silicon and bone mineral density: The Framingham study’, J. BoneMin. Res. 16: S510-S510, (2001)
Ricard-Blum, Sylvie. “The collagen family.” Cold Spring Harbor perspectives in biology 3.1 (2011): a004978.
Uthus, Eric O., and Carol D. Seaborn. “Deliberations and evaluations of the approaches, endpoints and paradigms for dietary recommendations of the other trace elements.” The Journal of nutrition 126.9 (1996): 2452S.